MicroRNAs are noncoding RNAs of ∼22 nucleotides that suppress translation of target
genes by binding to their mRNA and thus have a central role in gene regulation in health and …

MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that is involved in
oncogenesis and shows remarkable tissue specificity. Their potential for tumor classification …

p53 is a potent tumor suppressor, whose biological effects are largely due to its function as
a transcriptional regulator. Here we report that, in addition to regulating the expression of …

Purpose Recent advances in treatment of lung cancer require greater accuracy in the
subclassification of non–small-cell lung cancer (NSCLC). Targeted therapies which inhibit tumor …

In this paper we evaluate the prediction capability of various neural network models. The
models examined in this study differ on the following parameters: data span, learning technique …

A recurring challenge for brain pathologists is to diagnose whether a brain malignancy is a
primary tumor or a metastasis from some other tissue. The accurate diagnosis of brain …

Background. Cancers of unknown primary origin (CUP) constitute 3%–5% (50,000 to 70,000
cases) of all newly diagnosed cancers per year in the United States. Including cancers of …

Identification of the tissue of origin of a tumor is vital to its management. Previous studies
showed tissue-specific expression patterns of microRNA and suggested that microRNA …

Background and Aims microRNAs (miRNAs) are small noncoding RNAs that regulate
cognate mRNAs post-transcriptionally. miRNAs have been implicated in regulating gene …

… Genetically, this type of tumor is associated with polysomies of chromosomes 7 or 17 and
deficiency of Y. Chromophobe renal cell carcinoma was included before 1986 in the group of …