Signaling pathways for PC12 cell differentiation: making the right connections

D Vaudry, PJS Stork, P Lazarovici, LE Eiden - Science, 2002 - science.org
A key issue in signal transduction is how signaling pathways common to many systems—so-called
canonical signaling cassettes—integrate signals from molecules having a wide …

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

PJS Stork, JM Schmitt - Trends in cell biology, 2002 - cell.com
Hormonal stimulation of cyclic adenosine monophosphate (cAMP) and the cAMP-dependent
protein kinase PKA regulates cell growth by multiple mechanisms. A hallmark of cAMP is its …

Extracellular-signal-regulated kinase signalling in neurons

SS Grewal, RD York, PJS Stork - Current opinion in neurobiology, 1999 - Elsevier
Extracellular-signal-regulated kinases (ERKs) are emerging as important regulators of
neuronal function. Recent advances have increased our understanding of ERK signalling at the …

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

…, CL Ellig, SP Eckert, EW McCleskey, PJS Stork - Nature, 1998 - nature.com
Activation of mitogen-activated protein (MAP) kinase (also known as extracellular-signal-regulated
kinase, or ERK) 1 by growth factors can trigger either cell growth or differentiation. …

[HTML][HTML] cAMP activates MAP kinase and Elk-1 through a B-Raf-and Rap1-dependent pathway

…, H Yao, RD York, MG Pan, CS Rim, PJS Stork - Cell, 1997 - cell.com
Cyclic adenosine monophosphate (cAMP) has tissue-specific effects on growth, differentiation,
and gene expression. We show here that cAMP can activate the transcription factor Elk-1 …

A randomized trial of electronic versus paper pain diaries in children: impact on compliance, accuracy, and acceptability

TM Palermo, D Valenzuela, PP Stork - Pain, 2004 - journals.lww.com
… to children with p-diaries (M= 3.8), P< 0.001. Diaries returned by children in the p-diary …
e-diary group (which contained none), P< 0.001. Children rated both diary formats as highly …

[HTML][HTML] Allosteric activation of functionally asymmetric RAF kinase dimers

…, H Yu, EA Germino, HS Meharena, PJS Stork… - Cell, 2013 - cell.com
Although RAF kinases are critical for controlling cell growth, their mechanism of activation is
incompletely understood. Recently, dimerization was shown to be important for activation. …

Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

H Enslen, H Tokumitsu, PJ Stork… - Proceedings of the …, 1996 - National Acad Sciences
… For the kinase assay, 5-15 ,tg of plasmid encoding ERK2 tagged with the hemagglutinin
epitope (generously provided by P. Lenormand, Institut National de la Sante et de la Recherche …

[HTML][HTML] PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1

JM Schmitt, PJS Stork - Molecular cell, 2002 - cell.com
In fibroblast cells, cAMP antagonizes growth factor activation of ERKs and cell growth via
PKA and the small G protein Rap1. We demonstrate here that PKA's activation of Rap1 was …

Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1

…, PE Stenberg, EW McCleskey, PJS Stork - … and cellular biology, 2000 - Taylor & Francis
… The lipid products of PI3-Ks {PI 3-phosphate [PI(3)P], PI(3,4)P, PI(3,5)P, and PI(3,4,5)P} are
known to act as second messengers and mediate most of the known functions of PI3-Ks in …