Malignancies of the gastrointestinal tract are among the most common human cancers. The
distinct tissues of origin give rise to a diverse set of diseases, such as colorectal cancer, …

Background Chemotherapy (CT), radiotherapy (RT), and chemoradiotherapy (CRT) are able
to alter the composition of the tumor immune microenvironment (TIME). Understanding the …

Cancer is a collection of genetic diseases, with large phenotypic differences and genetic
heterogeneity between different types of cancers and even within the same cancer type. Recent …

Acetylcholine released by efferent vagus nerves inhibits macrophage activation. Here we
show that the anti-inflammatory action of nicotinic receptor activation in peritoneal …

Colon cancer is a clinically diverse disease. This heterogeneity makes it difficult to determine
which patients will benefit most from adjuvant therapy and impedes the development of …

Background Laparoscopic pancreatoduodenectomy may improve postoperative recovery
compared with open pancreatoduodenectomy. However, there are concerns that the extensive …

Background We studied causative pathogens, clinical characteristics, and outcome of adult
community-acquired bacterial meningitis after the introduction of adjunctive dexamethasone …

… These findings are suggestive for intercellular signalling actually occurring in vivo (MF
Bijlsma, unpublished data). In contrast with these findings are earlier reported experiments by …

A delicate equilibrium of WNT agonists and antagonists in the intestinal stem cell (ISC) niche
is critical to maintaining the ISC compartment, as it accommodates the rapid renewal of the …

… MF Bijlsma reported grants from Celgene and personal fees from Servier outside the
submitted work. HWM van Laarhoven reported grants and nonfinancial support from Roche, …