Although fungal infections contribute substantially to human morbidity and mortality, the
impact of these diseases on human health is not widely appreciated. Moreover, despite the …

The carbohydrate polymers known as β-1,3-d-glucans exert potent effects on the immune
system — stimulating antitumour and antimicrobial activity, for example — by binding to …

Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of
breast cancers and its target genes dictate cell growth and endocrine response, yet genomic …

▪ Abstract Macrophages express a broad range of plasma membrane receptors that mediate
their interactions with natural and altered-self components of the host as well as a range of …

The ability of fungal-derived β-glucan particles to induce leukocyte activation and the
production of inflammatory mediators, such as tumor necrosis factor (TNF)-α, is a well …

Dectin-1 is a natural killer (NK)-cell-receptor-like C-type lectin that is thought to be involved
in innate immune responses to fungal pathogens. This transmembrane signalling receptor …

The C-type lectin dectin-1 binds to yeast and signals through the kinase Syk and the
adaptor CARD9 to induce production of interleukin 10 (IL-10) and IL-2 in dendritic cells (DCs). …

β-Glucan is one of the most abundant polysaccharides in fungal pathogens, yet its importance
in antifungal immunity is unclear. Here we show that deficiency of dectin-1, the myeloid …

Zymosan is a β-glucan– and mannan-rich particle that is widely used as a cellular activator
for examining the numerous responses effected by phagocytes. The macrophage mannose …

The intestinal microflora, typically equated with bacteria, influences diseases such as obesity
and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich …