Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects

…, E Koponen, M Sairanen, E MacDonald… - Journal of …, 2003 - Soc Neuroscience
Recent studies have indicated that exogenously administered neurotrophins produce
antidepressant-like behavioral effects. We have here investigated the role of endogenous brain-…

Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB–PLCγ pathway, reduced anxiety, and facilitated …

E Koponen, V Võikar, R Riekki, T Saarelainen… - Molecular and Cellular …, 2004 - Elsevier
We have investigated the biochemical, physiological, and behavioral properties of transgenic
mice overexpressing the full-length neurotrophin receptor trkB (trkB.TK+). The highest trkB.…

[PDF][PDF] Big data in real estate? From manual appraisal to automated valuation

N Kok, EL Koponen… - The Journal of …, 2017 - maastrichtrealestate.com
August 2016 and makes up, on average, 5.1% of any institutional portfolio (Andonov, Eichholtz,
and Kok [2013]). Determining the value of commercial real estate remains elusively hard, …

Truncated trkB. T1 is dominant negative inhibitor of trkB. TK+-mediated cell survival

…, E Koponen, E Hoppe, G Wong, E Castrén - Biochemical and …, 2001 - Elsevier
Truncated trkB.T1 (T1) neurotrophin receptor inhibits full-length trkB.TK+ (TK+) signaling. At
least two possible mechanisms have been proposed for this action: T1 could trap the ligand …

Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines.

E Koponen, T Rantamäki, V Voikar… - Cellular and …, 2005 - europepmc.org
1. Neurotrophins and serotonin have both been implicated in the pathophysiology of
depression and in the mechanisms of antidepressant treatments. 2. Brain-derived neurotrophic …

Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia

…, OHJ Gröhn, J Jolkkonen, E Koponen… - Molecular and Cellular …, 2000 - Elsevier
It has been suggested that the increased production of endogenous BDNF after brain insults
supports the survival of injured neurons and limits the spread of the damage. In order to test …

Decreased BDNF signalling in transgenic mice reduces epileptogenesis

…, J Nissinen, E Koponen, E Castrén - European Journal of …, 2002 - Wiley Online Library
Brain derived neurotrophic factor (BDNF) has been suggested to be involved in epileptogenesis.
Both pro‐ and antiepileptogenic effects have been reported, but the exact physiological …

Overexpression of the full-length neurotrophin receptor trkB regulates the expression of plasticity-related genes in mouse brain

E Koponen, M Lakso, E Castrén - Molecular brain research, 2004 - Elsevier
Significant body of evidence indicates an important role for brain-derived neurotrophic factor
(BDNF) in the hippocampal synaptic plasticity; however, the exact mechanisms how the …

Acoustic pressure field estimation methods for synthetic schlieren tomography

E Koponen, J Leskinen, T Tarvainen… - The Journal of the …, 2019 - pubs.aip.org
Synthetic schlieren tomography is a recently proposed three-dimensional (3D) optical imaging
technique for studying ultrasound fields. The imaging setup is composed of an imaged …

BDNF regulates the expression of fragile X mental retardation protein mRNA in the hippocampus

M Castrén, KE Lampinen, R Miettinen, E Koponen… - Neurobiology of …, 2002 - Elsevier
Both fragile X mental retardation protein (FMRP) and brain-derived neurotrophic factor (BDNF)
are implicated in the maturation of neurons and in the higher cognitive functions. We …