Purpose : We provide a contemporary review of bladder tumor markers and summarize their
role as prognostic indicators. Materials and Methods : A comprehensive review of the …

Background We have previously demonstrated a strong association between nuclear
accumulation of p53 protein, as determined by immunohistochemical analysis, and mutations in …

Noninvasive transitional cell carcinomas of the bladder can have two distinct morphologies
suggesting they contain different genetic alterations. Papillary transitional cell carcinomas (T …

… The tumors in A and B did not demonstrate mtutations in thep53 gene hy wSSCP whereas
mutationzs were fotnnd in the tumors shoun in C and D (tuimors 24 and 20. respectively Table …

Urethral recurrence develops in roughly 10% of patients following cystectomy for bladder
cancer and appears to be another manifestation of the multicentric nature of TCC. By far the …

Background: Thrombospondin-1 (TSP) is a 430-kd glycoprotein that is an important
component of the extracellular matrix and is known to be a potent inhibitor of angiogenesis (ie, …

Background: Altered expression of p53 protein is an important predictor of progression in
bladder cancer. The action of p53 on cell cycle regulation is mediated, in part, through …

… (C) Estimated cumulative incidence curves for time to recurrence and (D) Kaplan-Meier
curves for overall survival among patients with p53-altered tumors in patients randomly assigned …

Purpose : We identified the risk of urethral recurrence following cystectomy for transitional cell
bladder carcinoma, stratified by pathological characteristics of the bladder tumor and type …

Purpose : Since 1986 orthotopic lower urinary tract reconstruction using the Kock ileal
neobladder has been our diversion of choice in patients undergoing cystectomy. We report on the …