Pax3 and Pax7 play distinct but overlapping roles in developmental and postnatal myogenesis.
The mechanisms involved in the differential regulation of these highly homologous …

Background Ischemia and reperfusion ( IR ) injury remains a major cause of morbidity and
mortality and multiple molecular and cellular pathways have been implicated in this injury. We …

Activation of protein kinase C (PKC) isozymes is associated with their translocation from the
cell-soluble fraction to the cell-particulate fraction, presumably near their protein substrates. …

There is substantial interest in the development of drugs that limit the extent of ischemia-induced
cardiac damage caused by myocardial infarction or by certain surgical procedures. Here…

… Authorship note: Xing Guo and Marie-Helene Disatnik contributed equally to this work. …
Authorship note: Xing Guo and Marie-Helene Disatnik contributed equally to this work. …

Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is emerging as a key enzyme involved
in cytoprotection in the heart. ALDH2 mediates both the detoxification of reactive aldehydes …

Several lines of evidence suggest that free radical mediated injury and oxidative stress may
lead to muscle necrosis in the muscular dystrophies, including those related to defects in the …

Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases,
including multiple cardiovascular disorders. However, translation of ROS scavengers (…

Aims Protein kinase C epsilon (PKCε) is critical for cardiac protection from ischaemia and
reperfusion (IR) injury. PKCε substrates that mediate cytoprotection reside in the mitochondria. …

The cardioprotective effects of moderate alcohol consumption have been well documented in
animal models and in humans. Protection afforded against ischemia and reperfusion injury …