The effective use of targeted therapy is highly dependent on the identification of responder
patient populations. Loss of FBW7, which encodes a tumour-suppressor protein, is frequently …

The article examines the importance of managerial skills across functional and general
management areas. It examines the influence of hierarchical level and functional specialty on …

Nodular fasciitis (NF) is a relatively common mass-forming and self-limited subcutaneous
pseudosarcomatous myofibroblastic proliferation of unknown pathogenesis. Due to its rapid …

This study tracked the leadership development of 236 male cadets from matriculation
through graduation at a military college. Cognitive ability, physical fitness, prior influence …

Aberrant Skp2 signaling has been implicated as a driving event in tumorigenesis. Although
the underlying molecular mechanisms remain elusive, cytoplasmic Skp2 correlates with …

Mixed lineage leukemia (MLL) and its metazoan Trithorax orthologs have been linked with
the epigenetic maintenance of transcriptional activity. To identify mechanisms by which MLL …

Oncogenic mutations in PIK3CA, the gene encoding the catalytic subunit of phosphoinositide
3-kinase (PI3K), occur with high frequency in breast cancer. The protein kinase Akt is …

Aneurysmal bone cyst (ABC) is an aggressive, pediatric bone tumor characterized by
extensive destruction of the surrounding bone. Although first described over 60 years ago, its …

Fbw7 is the substrate recognition component of the Skp1-Cullin-F-box (SCF)-type E3 ligase
complex and a well-characterized tumor suppressor that targets numerous oncoproteins for …

NF-κB/Rel is a family of transcription factors which are expressed in all cells; however, in
most non-B cells, they are sequestered in the cytoplasm in inactive complexes with specific …