OBJECTIVES: Linaclotide is a minimally absorbed guanylate cyclase-C agonist. The objective
of this trial was to determine the efficacy and safety of linaclotide in patients with irritable …

Background Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C
receptor. In two trials, we aimed to determine the efficacy and safety of linaclotide in patients …

INthe course of evaluating new approaches to the prevention of a disease, their acceptance
generally can be characterized as evolving through three levels: the possibly beneficial, the …

Objective —To determine sedative and cardiorespiratory effects of IM administration of
medetomidine alone and in combination with butorphanol or ketamine in dogs. Design —…

Objective —To identify factors associated with gastrointestinal tract perforation in dogs
being treated with a selective cyclooxygenase-2 (COX-2) inhibitor (deracoxib). Design —…

The four known members of the tetracycline family of broad-spectrum antibiotics (tetracycline,
7-chlorotetracycline, 7-bromotetracycline and 5-hydroxytetracycline) can undergo a …

Plasma cortisol concentrations were determined before, during and after analgesia,
anaesthesia and anaesthesia plus ovariohysterectomy in six New Zealand border collie cross …

An effort is made to present a realistic view of municipal police as they interact with other
citizens. Only when a partnership exists can municipal police forces perform their tasks as …

Objective —To evaluate effects of medetomidine on anesthetic dose requirements,
cardiorespiratory variables, plasma cortisol concentrations, and behavioral pain scores in dogs …

Background Abdominal bloating is a common and bothersome symptom of chronic idiopathic
constipation. The objective of this trial was to evaluate the efficacy and safety of linaclotide …