User profiles for L. Heckman

Lars-Henrik Lau Heckmann

SKOV A/S
Verified email at heckmann.co.uk
Cited by 3088

The chemistry of small-molecule fluorogenic probes

JB Grimm, LM Heckman, LD Lavis - Progress in molecular biology and …, 2013 - Elsevier
Chemical fluorophores find wide use in biology to detect and visualize different phenomena.
A key advantage of small-molecule dyes is the ability to construct compounds where …

Left bundle branch area pacing outcomes: the multicentre European MELOS study

…, G Kiełbasa, O Cano, K Curila, L Heckman… - European heart …, 2022 - academic.oup.com
Aims Permanent transseptal left bundle branch area pacing (LBBAP) is a promising new
pacing method for both bradyarrhythmia and heart failure indications. However, data regarding …

Rethinking organic wastes bioconversion: Evaluating the potential of the black soldier fly (Hermetia illucens (L.))(Diptera: Stratiomyidae)(BSF)

…, A van Huis, JA Cammack, LHL Heckmann… - Waste Management, 2020 - Elsevier
Population growth and unprecedented economic growth and urbanization, especially in low-
and middle-income countries, coupled with extreme weather patterns, the high-…

[HTML][HTML] Left bundle branch pacing compared to left ventricular septal myocardial pacing increases interventricular dyssynchrony but accelerates left ventricular lateral …

…, P Moskal, M Susankova, L Znojilova, L Heckman… - Heart rhythm, 2021 - Elsevier
Background Nonselective His-bundle pacing (nsHBp), nonselective left bundle branch
pacing (nsLBBp), and left ventricular septal myocardial pacing (LVSP) are recognized as …

Short-term hemodynamic and electrophysiological effects of cardiac resynchronization by left ventricular septal pacing

…, SW Westra, B Weijs, EB Engels, LIB Heckman… - Journal of the American …, 2020 - jacc.org
Background Cardiac resynchronization therapy (CRT) is usually performed by biventricular (BiV)
pacing. Previously, feasibility of transvenous implantation of a lead at the left ventricular …

Novel bradycardia pacing strategies

L Heckman, P Vijayaraman, J Luermans… - Heart, 2020 - heart.bmj.com
The adverse effects of ventricular dyssynchrony induced by right ventricular (RV) pacing
has led to alternative pacing strategies, such as biventricular, His bundle (HBP), LV septal (…

Regulatory experiences with root causes and risk factors for nitrosamine impurities in pharmaceuticals

…, LR Nagavelli, VA Sayeed, L Heckman… - Journal of …, 2023 - Elsevier
N-Nitrosamines (also referred to as nitrosamines) are a class of substances, many of which
are highly potent mutagenic agents which have been classified as probable human …

Biallelic mutations in the 3′ exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing

…, B Rosti, N Akizu, E Scott, JL Silhavy, LD Heckman… - Nature …, 2017 - nature.com
Deadenylases are best known for degrading the poly(A) tail during mRNA decay. The
deadenylase family has expanded throughout evolution and, in mammals, consists of 12 Mg 2+ -…

Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice

LD Heckman, MH Chahrour, HY Zoghbi - Elife, 2014 - elifesciences.org
Heckman et al. have now engineered mice that also have an extra human MECP2 gene
but with one of two mutations that cause Rett syndrome in humans. Some mice had a mutation …

[HTML][HTML] Comparing ventricular synchrony in left bundle branch and left ventricular septal pacing in pacemaker patients

LIB Heckman, JGLM Luermans, K Curila… - Journal of Clinical …, 2021 - mdpi.com
Background: Left bundle branch area pacing (LBBAP) has recently been introduced as a
novel physiological pacing strategy. Within LBBAP, distinction is made between left bundle …