The development of new CRISPR–Cas genome editing tools continues to drive major
advances in the life sciences. Four classes of CRISPR–Cas-derived genome editing agents—…

… Zhang, YY Li, and D. Liu and Drs. Shen, Xu, and Wong contributed equally to this letter.
Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org. …

Metaverse, as an evolving paradigm of the next-generation Internet, aims to build a fully
immersive, hyper spatiotemporal, and self-sustaining virtual shared space for humans to play, …

… D, Change in body temperature of the 5 patients following plasma transfusion. … and
declined to the normal range on the third day after the transfusion (Table 2 and Figure 1D). …

Metal–organic frameworks (MOFs), a class of hybrid materials formed by the self-assembly
of polydentate bridging ligands and metal-connecting points, have been studied for a variety …

Variations in maternal care affect the development of individual differences in neuroendocrine
responses to stress in rats. As adults, the offspring of mothers that exhibited more licking …

The Daya Bay Reactor Neutrino Experiment has measured a nonzero value for the neutrino
mixing angle θ 13 with a significance of 5.2 standard deviations. Antineutrinos from six 2.9 …

Because this is the first large cohort study on this topic, our report will provide much-needed
information that will benefit patients with cancer globally. As such, we believe it is extremely …

Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-…

… (c) Lung histopathology (original magnification ×200) and (d) lung injury scores as defined
by leukocyte infiltration of control and SARS-CoV–infected wild-type and Ace2 knockout mice. …