Classification of amyloidosis by laser microdissection and mass spectrometry–based proteomic analysis in clinical biopsy specimens

JA Vrana, JD Gamez, BJ Madden… - Blood, The Journal …, 2009 - ashpublications.org
The clinical management of amyloidosis is based on the treatment of the underlying etiology,
and accurate identification of the protein causing the amyloidosis is of paramount …

Characterization of PKD protein-positive exosome-like vesicles

…, AA Leontovich, TG Beito, BJ Madden… - Journal of the …, 2009 - journals.lww.com
Proteins associated with autosomal dominant and autosomal recessive polycystic kidney
disease (polycystin-1, polycystin-2, and fibrocystin) localize to various subcellular …

Exostosin 1/exostosin 2–associated membranous nephropathy

S Sethi, BJ Madden, H Debiec… - Journal of the …, 2019 - journals.lww.com
Background In membranous nephropathy (MN), which is characterized by deposition of
immune complexes along the glomerular basement membrane (GBM), phospholipase A2 …

[HTML][HTML] Proteome analysis of human aqueous humor

UR Chowdhury, BJ Madden… - … & visual science, 2010 - iovs.arvojournals.org
Purpose.: Human aqueous humor (hAH) provides nutrition and immunity within the anterior
chamber of the eye. Characterization of the protein composition of hAH will identify …

Identification of biomarkers for PKD1 using urinary exosomes

…, KL Johnson, BJ Madden… - Journal of the …, 2015 - journals.lww.com
Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of ESRD. Affected
individuals inherit a defective copy of either PKD1 or PKD2, which encode polycystin-1 (…

[HTML][HTML] Subfractionation, characterization, and in-depth proteomic analysis of glomerular membrane vesicles in human urine

…, RM Zenka, MC Charlesworth, BJ Madden… - Kidney international, 2014 - Elsevier
Urinary exosome-like vesicles (ELVs) are a heterogenous mixture (diameter 40–200 nm)
containing vesicles shed from all segments of the nephron including glomerular podocytes. …

[HTML][HTML] An acetylation–phosphorylation switch that regulates tau aggregation propensity and function

…, M Yue, M Castanedes-Casey, BJ Madden… - Journal of Biological …, 2017 - ASBMB
The aberrant accumulation of tau protein is a pathological hallmark of a class of
neurodegenerative diseases known as tauopathies, including Alzheimer's disease and related …

Understanding protein–nanoparticle interaction: a new gateway to disease therapeutics

…, A Sharma, RR Arvizo, BJ Madden… - Bioconjugate …, 2014 - ACS Publications
Molecular identification of protein molecules surrounding nanoparticles (NPs) may provide
useful information that influences NP clearance, biodistribution, and toxicity. Hence, …

[HTML][HTML] In patients with membranous lupus nephritis, exostosin-positivity and exostosin-negativity represent two different phenotypes

…, V Negron, GE Jenson, BJ Madden… - Journal of the …, 2021 - journals.lww.com
Background In patients with secondary (autoimmune) membranous nephropathy, two novel
proteins, Exostosin 1 and Exostosin 2 (EXT1/EXT2), are potential disease antigens, …

Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA.

…, ED Wieben, TC Wood, WG Watson, BJ Madden… - Molecular …, 1992 - ASPET
Sulfation is an important pathway in the metabolism of many hormones and drugs. Human
liver contains at least three well characterized sulfotransferase (ST) enzymes, ie, …